Neeraj Gupta Selected Research

ixazomib

1/2022	Population pharmacokinetic/pharmacodynamic joint modeling of ixazomib efficacy and safety using data from the pivotal phase III TOURMALINE-MM1 study in multiple myeloma patients.
1/2019	Phase 2 study of all-oral ixazomib, cyclophosphamide and low-dose dexamethasone for relapsed/refractory multiple myeloma.
1/2019	Oral ixazomib maintenance following autologous stem cell transplantation (TOURMALINE-MM3): a double-blind, randomised, placebo-controlled phase 3 trial.
1/2019	All-oral ixazomib, cyclophosphamide, and dexamethasone for transplant-ineligible patients with newly diagnosed multiple myeloma.
1/2019	Clinical Pharmacology of Ixazomib: The First Oral Proteasome Inhibitor.
11/2018	Biotransformation of [14C]-ixazomib in patients with advanced solid tumors: characterization of metabolite profiles in plasma, urine, and feces.
1/2018	Effects of Strong CYP3A Inhibition and Induction on the Pharmacokinetics of Ixazomib, an Oral Proteasome Inhibitor: Results of Drug-Drug Interaction Studies in Patients With Advanced Solid Tumors or Lymphoma and a Physiologically Based Pharmacokinetic Analysis.
1/2018	A phase I/II dose-escalation study investigating all-oral ixazomib-melphalan-prednisone induction followed by single-agent ixazomib maintenance in transplant-ineligible newly diagnosed multiple myeloma.
1/2018	A Phase 1 Study to Assess the Relative Bioavailability of Two Capsule Formulations of Ixazomib, an Oral Proteasome Inhibitor, in Patients With Advanced Solid Tumors or Lymphoma.
1/2018	A phase I study to assess the mass balance, excretion, and pharmacokinetics of [14C]-ixazomib, an oral proteasome inhibitor, in patients with advanced solid tumors.

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Neeraj Gupta Research Topics

Disease

25	Multiple Myeloma 01/2022 - 08/2014
23	Neoplasms (Cancer) 05/2022 - 05/2009
11	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2022 - 08/2011
8	Fatigue 01/2018 - 10/2009
8	Thrombocytopenia (Thrombopenia) 10/2017 - 08/2014
7	Exanthema (Rash) 01/2022 - 08/2014
6	Nausea 01/2022 - 08/2011
6	Diarrhea 01/2022 - 08/2011
6	Lymphoma (Lymphomas) 01/2018 - 05/2015
5	Body Weight (Weight, Body) 01/2022 - 05/2010
5	Clubfoot (Talipes Equinovarus) 03/2020 - 04/2012
5	Peripheral Nervous System Diseases (PNS Diseases) 01/2018 - 08/2014
5	Type 2 Diabetes Mellitus (MODY) 01/2014 - 12/2009
4	Asthma (Bronchial Asthma) 09/2021 - 10/2018
4	Sepsis (Septicemia) 06/2020 - 10/2015
4	Neutropenia 01/2016 - 08/2014
4	Metabolic Syndrome (Dysmetabolic Syndrome X) 12/2012 - 12/2009
3	Lung Neoplasms (Lung Cancer) 01/2022 - 01/2020
3	Weight Loss (Weight Reduction) 01/2021 - 05/2010
3	Hypersensitivity (Allergy) 01/2020 - 10/2016
3	Pain (Aches) 04/2015 - 07/2008
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2022 - 01/2017
2	Hematologic Neoplasms (Hematological Malignancy) 01/2022 - 06/2015
2	Hyperglycemia 01/2022 - 05/2010
2	Birth Weight (Birth Weights) 01/2021 - 01/2019
2	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 05/2020 - 07/2018
2	Pulmonary Atelectasis 05/2020 - 01/2019
2	Respiratory Sounds (Crackle) 05/2020 - 01/2019
2	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2019 - 04/2015
2	Disease Progression 01/2019 - 11/2018
2	Vomiting 08/2014 - 10/2013
2	Proteinuria 08/2011 - 10/2009
2	Hypertension (High Blood Pressure) 08/2011 - 10/2009
2	Insulin Resistance 05/2010 - 12/2009
1	Vitamin D Deficiency 09/2022
1	Rickets (Rachitis) 09/2022
1	Stomatitis 01/2022
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2022
1	Milk Hypersensitivity (Milk Allergy) 01/2022
1	Philadelphia Chromosome 01/2022
1	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2022
1	Pleural Diseases 10/2021
1	Allergic Rhinitis 08/2021
1	Airway Obstruction (Choking) 07/2021
1	Acquired Immunodeficiency Syndrome (AIDS) 02/2021
1	Opportunistic Infections (Opportunistic Infection) 02/2021

Drug/Important Bio-Agent (IBA)

29	ixazomibIBA 01/2022 - 08/2014
20	Proteasome InhibitorsIBA 01/2022 - 08/2014
15	Pharmaceutical PreparationsIBA 07/2018 - 10/2009
13	Dexamethasone (Maxidex)FDA LinkGeneric 01/2022 - 12/2014
11	Lenalidomide (CC 5013)FDA Link 01/2022 - 08/2014
9	brigatinibIBA 01/2022 - 11/2018
7	Anaplastic Lymphoma KinaseIBA 01/2022 - 11/2018
7	CrizotinibIBA 01/2022 - 11/2018
5	CreatinineIBA 01/2022 - 01/2016
5	Insulin (Novolin)FDA Link 12/2012 - 12/2009
4	Tyrosine Kinase InhibitorsIBA 01/2022 - 01/2021
4	Bortezomib (Velcade)FDA Link 01/2017 - 08/2014
3	Phosphotransferases (Kinase)IBA 01/2022 - 12/2020
3	mobocertinibIBA 01/2022 - 01/2021
3	Adrenal Cortex Hormones (Corticosteroids)IBA 09/2021 - 10/2016
3	Epinephrine (Adrenaline)FDA LinkGeneric 05/2019 - 07/2012
3	Hypoglycemic Agents (Hypoglycemics)IBA 12/2012 - 07/2012
3	linifanibIBA 12/2011 - 10/2009
2	sapanisertibIBA 05/2022 - 01/2022
2	ErbB Receptors (EGF Receptor)IBA 01/2022 - 01/2022
2	PlatinumIBA 01/2022 - 01/2022
2	BilirubinIBA 01/2022 - 01/2021
2	simurosertibIBA 01/2022 - 01/2022
2	AlbuminsIBA 01/2022 - 06/2020
2	Alanine Transaminase (SGPT)IBA 01/2022 - 01/2021
2	Oxygen (Dioxygen)IBA 01/2021 - 05/2020
2	Melphalan (Alkeran)FDA LinkGeneric 01/2019 - 01/2018
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2019 - 01/2019
2	Immunoglobulin Light Chains (Immunoglobulin Light Chain)IBA 01/2017 - 09/2015
2	SmokeIBA 09/2016 - 12/2013
2	Proteasome Endopeptidase Complex (Proteasome)IBA 06/2015 - 08/2014
2	VaccinesIBA 04/2012 - 03/2009
2	Biomarkers (Surrogate Marker)IBA 10/2009 - 10/2008
1	Vitamin D FDA LinkGeneric 09/2022
1	Proteins (Proteins, Gene)FDA Link 01/2022
1	Milk Proteins (Milk Protein)IBA 01/2022
1	ponatinibIBA 01/2022
1	Alkaline PhosphataseIBA 01/2022
1	Air Pollutants (Pollutants, Air)IBA 08/2021
1	Albuterol (Salbutamol)FDA LinkGeneric 05/2021
1	Blood Glucose (Blood Sugar)IBA 01/2021

Therapy/Procedure

21	Therapeutics 02/2021 - 02/2009
5	Drug Therapy (Chemotherapy) 01/2022 - 09/2014
5	Artificial Respiration (Mechanical Ventilation) 07/2021 - 04/2016
4	Length of Stay 07/2021 - 07/2012
4	Tenotomy 09/2018 - 04/2012
4	Gastrectomy 12/2012 - 12/2009
2	Operative Surgical Procedures 10/2021 - 12/2009
2	Mechanical Ventilators (Ventilator) 01/2019 - 01/2018
2	Bariatric Surgery 01/2014 - 12/2009
1	Oral Administration 01/2022
1	Diet Therapy (Therapy, Diet) 01/2022
1	Conscious Sedation 10/2021
1	Continuous Positive Airway Pressure 01/2021